2007年8月毕业于华中科技大学同济医学院,毕业后一直在浙江大学医学院附属妇产科医院从事妇产科的临床及科研工作。2007年获妇产科博士学位,2015-2017年赴美国国立卫生研究院/国家转化科学促进中心(NIH/NCATS)学习,主要从事卵巢癌药物筛选方面的研究。目前任浙江省医学会妇科肿瘤学分会青年委员兼秘书。已发表论文近10篇,主持国家自然科学基金2项。
发表的主要论著:
[1] Sima N, Cheng X, Ye F, Ma D, Xie X, Lu W. The Overexpression of Scaffolding Protein NEDD9 Promotes Migration and Invasion in Cervical Cancer via Tyrosine Phosphorylated FAK and SRC. PLoS One 2013; 8(9): e74594.
[2] Sima N, Lu W, Xie X. Early proteins E6 and E7 of human papillomavirus may attenuate ischemia-reperfusion injury. Med Hypotheses 2011; 76(4): 607-9.
[3] Sima N, Wang W, Kong D, Deng D, Xu Q, Zhou J, Xu G, Meng L, Lu Y, Wang S, Ma D. RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53. Apoptosis 2008; 13(2): 273-81.
[4] Sima N, Wang S, Wang W, Kong D, Xu Q, Tian X, Luo A, Zhou J, Xu G, Meng L, Lu Y, Ma D. Antisense targeting human papillomavirus type 16 E6 and E7 genes contributes to apoptosis and senescence in SiHa cervical carcinoma cells. Gynecol Oncol 2007; 106(2): 299-304.
[5] Sima N, Cai L, Zhu Y, Wang W, Wang S, Ma D. Relationship between the expression of telomerase and human papillomavirus infection in invasive uterine cervical carcinoma. J Huazhong Univ Sci Technolog Med Sci 2007; 27(4): 451-3.
[6] Wang W, Sima N, Kong D, Luo A, Gao Q, Liao S, Li W, Han L, Wang J, Wang S, Lu Y, Wang D, Xu G, Zhou J, Meng L, Ma D. Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo. Cancer Lett 2010; 291(1): 67-75.
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